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Filtering by: Alternative title ssim EC 706 Remove constraint Alternative title ssim: EC 706 Committee Member Williams, David Remove constraint Committee Member: Williams, David

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  • Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

    Creator:
    Larsen, Christine A.
    Abstract:
    Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
    Resource Type:
    Dissertation
    Full Text:
    of the MET kinase active site with bound CAT (purple), EC (green), and EGC (blue

  • Studies on isoprenoid biosynthesis in Euglena gracilis

    Creator:
    Kim, Dojung
    Abstract:
    This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
    Resource Type:
    Dissertation
    Full Text:
    enzyme acetoacetyl-CoA thiolase (EC 2.3.1.9) to produce acetoacetyl-CoA. In the second step, 3-hydroxy-3

  • A proteomic approach to 1,2-dichloroethane bioactivation and reaction with redox-active protein disulfide isomerase

    Creator:
    Kaetzel, Rhonda Sue
    Abstract:
    Protein disulfide isomerase (PDI), a member of the thioredoxin superfamily, contains two domains with significant sequence homology to the active sites in thioredoxin. PDI facilitates the folding of nascent proteins in the endoplasmic reticulum (ER), binds hormones and Ca²⁺, catalyzes the glutathione dependent reduction of dehydroascorbate, serves as a major...
    Resource Type:
    Dissertation
    Full Text:
    on the redox-active protein disulfide isomerase (EC 5.3.4.1), a member of the thioredoxin

  • Unraveling tissue regeneration using chemical genetics

    Creator:
    Mathew, Lijoy K.
    Abstract:
    The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
    Resource Type:
    Dissertation