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Filtering by: Creator Greenwood, Jeffrey A. Remove constraint Creator: Greenwood, Jeffrey A. Committee Member Williams, David Remove constraint Committee Member: Williams, David

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  • Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

    Creator:
    Shenvi, Swapna V.
    Abstract:
    Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and

  • Biochemical and physiological indicators of behavioral impairment in salmonids exposed to chlorpyrifos and copper

    Creator:
    Sandahl, Jason
    Abstract:
    The purpose of this work was to determine if environmentally-relevant concentrations of chlorpyrifos and copper, two commonly detected chemicals in Western surface waters, can negatively impact the biological health of salmonids. Both compounds are highly neurotoxic to fish, but each with distinct biological target sites and mechanisms of action. We...
    Resource Type:
    Dissertation
    Full Text:
    I thank my mentor, Jeffrey Jenkins, for his efforts in shaping my development as a scientist, and

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
    Resource Type:
    Dissertation
    Full Text:
    by Jeffrey S. Monette A DISSERTATION Submitted to Oregon State University In

  • Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

    Creator:
    De Lorme, Marthah J. M.
    Abstract:
    2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: ________________________________________________ A. Morrie Craig 2,4,6

  • Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

    Creator:
    Wang, Qi
    Abstract:
    Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
    Resource Type:
    Masters Thesis
    Full Text:
    approved: Mitchell S. Turker Mitotic recombination is a common autosomal mutation in mammalian cells

  • Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

    Creator:
    Larsen, Christine A.
    Abstract:
    Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
    Resource Type:
    Dissertation
    Full Text:
    Doctor of Philosophy dissertation of Christine A AN

  • Development and application of a new passive sampling device : the lipid-free tube (LFT) sampler

    Creator:
    Quarles, Lucas W.
    Abstract:
    Contaminants can exist in a wide range of states in aqueous environments, especially in surface waters. They can be freely dissolved or associated with dissolved or particulate organic matter depending on their chemical and physical characteristics. The freely dissolved fraction represents the most bioavailable fraction to an organism. These freely...
    Resource Type:
    Masters Thesis
    Full Text:
    .; Allan, I. J.; Greenwood, R.; Mills, G. A.; Dominiak, E.; Svensson, K.; Knutsson, J.; Morrison, G

  • Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

    Creator:
    Courter, Lauren A.
    Abstract:
    Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
    Resource Type:
    Dissertation
    Full Text:
    . Jeffrey, A. M., Weinstein, I. B., Jennette, K. W., Grzeskowiak, K., Nakanishi, K., Harvey, R. G., Autrup

  • Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

    Creator:
    Bajaj, Gaurav
    Abstract:
    EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
    Resource Type:
    Dissertation
    Full Text:
    proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse

  • Unraveling tissue regeneration using chemical genetics

    Creator:
    Mathew, Lijoy K.
    Abstract:
    The emerging field of regenerative medicine is mainly approached by two different aspects. First is the use of stem cell based models to generate a suite of differentiated cells for therapeutic applications and the alternative approach is to utilize the non-mammalian models that have the inherent capacity to regenerate their...
    Resource Type:
    Dissertation
    Full Text:
    aspects. First is the use of stem cell based models to generate a suite of differentiated cells for