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Filtering by: Alternative title ssim Induced variability and mutations in beans Remove constraint Alternative title ssim: Induced variability and mutations in beans Committee Member Williams, David Remove constraint Committee Member: Williams, David

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  • Factors contributing to the formation of CC-->TT tandem mutations

    Creator:
    Skinner, Amy M.
    Abstract:
    The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
    Resource Type:
    Dissertation
    Full Text:
    multiple databases containing more than 12,000 mutations (spontaneous or induced) in mammalian and

  • Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

    Creator:
    Courter, Lauren A.
    Abstract:
    Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
    Resource Type:
    Dissertation
    Full Text:
    Chapter 5: DIESEL EXHAUST INFLUENCES CARCINOGENIC PAH- INDUCED GENOTOXICIY AND GENE EXPRESSION IN HUMAN

  • In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

    Creator:
    Usenko, Crystal Y.
    Abstract:
    Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
    Resource Type:
    Masters Thesis
    Full Text:
    morphological and behavioral responses. Exposure to C60 and C70 induced a significant increase in

  • Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

    Creator:
    Wang, Qi
    Abstract:
    Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
    Resource Type:
    Masters Thesis
    Full Text:
    radiation (IR)-induced autosomal mutations affecting Aprt activity in a mouse kidney cell line null for

  • Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

    Creator:
    Larsen, Christine A.
    Abstract:
    Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
    Resource Type:
    Dissertation
    Full Text:
    secondary structure and defined by having three conserved disulfide bonds. As a result of mutations in

  • A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

    Creator:
    Myzak, Melinda C.
    Abstract:
    Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
    Resource Type:
    Dissertation
    Full Text:
    induced histone acetylation at 6 and 24 h in mouse colonic mucosa, and long-term dietary SFN treatment

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
    Resource Type:
    Dissertation
    Full Text:
    as ethanol-induced 6 liver disease, diabetes, and atherosclerosis (10, 16-26). In organ

  • Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

    Creator:
    Shenvi, Swapna V.
    Abstract:
    Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
    Resource Type:
    Dissertation
    Full Text:
    systems and cellular repair systems have shown to be induced in response to oxidative challenges (47

  • The mechanism of interaction of the linker histone with DNA and nucleosomes

    Creator:
    Ellen, Thomas Patrick
    Abstract:
    This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously reported to influence the linker histone's interaction with DNA were examined: ratio of linker histone to...
    Resource Type:
    Dissertation
    Full Text:
    is bent, and follows the path induced by the nucleosome cores. In the zig-zag-type model the linker

  • Prostate cancer prevention with broccoli : from cellular to human studies

    Creator:
    Clarke, John D.
    Abstract:
    Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
    Resource Type:
    Dissertation
    Full Text:
    the promoter for P21, induced p21 expression and increased tubulin acetylation in prostate cancer