Index Catalog // ScholarsArchive@OSU

Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

Creator:: Samon, Samantha M.
Abstract:: Exposure assessment is necessary to determine the frequency and magnitude of environmental contaminants, especially since exposure may lead to adverse health outcomes. Traditional personal exposure assessment tools such as biological samples are limited in their ability to capture a wide range of chemical exposures from a single sample, and others...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Samantha M. Samon for the degree of Doctor of Philosophy in Toxicology presented on April

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Creator:: Tidwell, Lane G.
Abstract:: Passive sampling devices (PSDs) were used to measure air vapor and water dissolved phase concentrations of polycyclic aromatic hydrocarbons (PAHs) and oxygenated PAHs (OPAHs) at two different environmentally contaminated sites. Environmental contaminates like PAHs and OPAHs are present in both the atmospheric and aqueous environmental compartments. It is known that...
Resource Type:: Dissertation
Full Text:: five PSDs were deployed in each air or water cage. Air samplers were located between 1-5 m above the

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: ). Specifically Sec8 and m-Pins associate with NR1/NR2B or NR1/NR2A through SAP-102 or PSD-95 to form a NMDA

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

Creator:: Tsai, Hsi-Wen
Abstract:: Zebrafish (Brachydanio rerio) are small, freshwater teleost fishes in the family Cyprinidae, the true minnows. They are native to the tropical latitudes of India, but have become widespread through their use as aquarium fish and as models for several branches of biological research. Their ease of rearing, short generation time,...
Resource Type:: Dissertation
Full Text:: including Sheila Cleveland, Chance Macdonald, Jean Bamhill, and Connie Owston for assistance with necropsy

A study of antimutagenicity in yogurt

Creator:: Sudarshan, Nadathur R.
Abstract:: The purpose of this study was to identify antimutagens in yogurt active against the experimental colon carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Our initial experiments showed that acetone extracts of yogurt, or milk fermented by various lactic acid bacteria were antimutagenic against MNNG and 3,2'-dimethyl-4-aminobiphenyl (DMAB) in the Ames test (Salmonella typhimurium TA...
Resource Type:: Dissertation
Full Text:: them less accessible to mutagens. MacDonald et al., (1994) reported that fermentation of media

Spatial and temporal variations of bioavailable polycyclic aromatic hydrocarbons in the lower Willamette River

Creator:: Sower, Gregory J.
Abstract:: Urban rivers with a history of industrial use can exhibit spatial and temporal variations in contaminant concentrations that may significantly affect risk evaluations and assessment of remediation efforts. To more effectively estimate human and ecological health risks, we evaluated the spatial and temporal distribution of polycyclic aromatic hydrocarbons (PAHs) in...
Resource Type:: Dissertation
Full Text:: .; Liem, D. A. K.; Steen, J. M. D.; Hutzinger, O., Relationship between bioconcentration in fish and

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation
Full Text:: and G2/M cell cycle arrest has been observed after treatment with HDAC inhibitors. Various mechanisms

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Creator:: Roy, Shukla
Resource Type:: Dissertation
Full Text:: affinity of several transcription factors. 5 References Ilian, M. A., Sparrow, B. R., Ryu, B.W

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: same study showed that CD pretreatment altered lipoprotein metabolism and, further, that CD (10 μM

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

Creator:: Taur, Jan-Shiang
Abstract:: The goal of this dissertation is to investigate the interaction between cimetidine and dietary flavonoids using the Caco-2 cell transport model. It has been shown that flavonoids can change the bioavailability of pharmaceuticals, either by inhibiting metabolizing enzymes or inhibiting the drug efflux transporters. However, the effect of dietary flavonoids...
Resource Type:: Dissertation
Full Text:: -treatment of lOOj.t M fiavonoid aglycones in Caco-2 cell monolayers

ScholarsArchive@OSU

Exploring Silicone Wristbands as Personal Passive Sampling Devices in a Disaster Scenario

New Applications for Passive Samplers : In-situ Flux and Risk Assessment of Legacy and Emerging Contaminants

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Evaluation of zebrafish (Brachydanio rerio) as a model for carcinogenesis

A study of antimutagenicity in yogurt

Spatial and temporal variations of bioavailable polycyclic aromatic hydrocarbons in the lower Willamette River

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Regulation of hepatic pyruvate carboxylase in 2,3,7,8-Tetrachlorodibenzo-p-dioxin treated C57BL/6J mice and their pair-fed controls

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Alterations in the permeability of cimetidine by dietary flavonoids using an in vitro transport model, Caco-2 cell

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