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Filtering by: Creator Masek, Jeffrey G. Remove constraint Creator: Masek, Jeffrey G. Committee Member Williams, David Remove constraint Committee Member: Williams, David

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  • Biochemical and physiological indicators of behavioral impairment in salmonids exposed to chlorpyrifos and copper

    Creator:
    Sandahl, Jason
    Abstract:
    The purpose of this work was to determine if environmentally-relevant concentrations of chlorpyrifos and copper, two commonly detected chemicals in Western surface waters, can negatively impact the biological health of salmonids. Both compounds are highly neurotoxic to fish, but each with distinct biological target sites and mechanisms of action. We...
    Resource Type:
    Dissertation
    Full Text:
    I thank my mentor, Jeffrey Jenkins, for his efforts in shaping my development as a scientist, and

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
    Resource Type:
    Dissertation
    Full Text:
    AN ABSTRACT OF THE DISSERTATION OF Jeffrey

  • Biotransformation of 2,4,6-trinitrotoluene by ruminal organisms

    Creator:
    De Lorme, Marthah J. M.
    Abstract:
    2,4,6-Trinitrotoluene (TNT) has been the common munitions used in the world and is an environmental contaminant that is amendable to reductive transformation reactions. The rumen is an extremely reductive environment containing diverse microbial populations. There are 21 pure culture ruminal bacteria species in culture collection, these were tested for the...
    Resource Type:
    Dissertation
    Full Text:
    media with 40% clarified rumen fluid (per liter: 400 ml clarified rumen fluid; 2.0 g trypticase; 1.0 g

  • Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

    Creator:
    Shenvi, Swapna V.
    Abstract:
    Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and

  • Hypermutagenic induction of mitotic recombination by ionizing radiation in Mlhl null mouse cells

    Creator:
    Wang, Qi
    Abstract:
    Mitotic recombination is a common autosomal mutation in mammalian cells involving crossover events between homologous chromosomes. This process can convert a cell with a heterozygous deficiency to one with a homozygous deficiency, and thus often represents the second step in tumor suppressor gene inactivation. In this study I examined the...
    Resource Type:
    Masters Thesis
    Full Text:
    . Andrew Buermeyer, Prof. David Williams and Prof. Jeffrey Stone for their wise counsel and support. I

  • Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

    Creator:
    Courter, Lauren A.
    Abstract:
    Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
    Resource Type:
    Dissertation
    Full Text:
    . Jeffrey, A. M., Weinstein, I. B., Jennette, K. W., Grzeskowiak, K., Nakanishi, K., Harvey, R. G., Autrup

  • Suppression of Met signaling by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG)

    Creator:
    Larsen, Christine A.
    Abstract:
    Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
    Resource Type:
    Dissertation
    Full Text:
    (EGCG). A typical cup of brewed green tea has been defined as 2 g of tea leaves in 200 mL of hot

  • The mechanism of interaction of the linker histone with DNA and nucleosomes

    Creator:
    Ellen, Thomas Patrick
    Abstract:
    This dissertation examines the interaction of the linker histone with DNA and with nucleosomes. The first goal of the project was to characterize the interaction of the linker histone with DNA. Three factors previously reported to influence the linker histone's interaction with DNA were examined: ratio of linker histone to...
    Resource Type:
    Dissertation
    Full Text:
    go to Dr. Jeffrey Hansen, University of Texas Health Science Center, San Antonio, and his graduate

  • Prostate cancer prevention with broccoli : from cellular to human studies

    Creator:
    Clarke, John D.
    Abstract:
    Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
    Resource Type:
    Dissertation
    Full Text:
    of broccoli extracts (equivalent to ~1.2 g dry weight broccoli) resulted in an induction of GSTA1