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Filtering by: Creator Taylor, Dennis William Remove constraint Creator: Taylor, Dennis William Committee Member Williams, David Remove constraint Committee Member: Williams, David

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  • Factors contributing to the formation of CC-->TT tandem mutations

    Creator:
    Skinner, Amy M.
    Abstract:
    The multistage model of carcinogenesis states that an accumulation of mutations in genes that are important for maintaining cellular homeostasis may lead to cancer. A specific type of mutation observed in particular types of cancer is the CC-->TT mutation found in the TP53 gene of patients with basal or squamous...
    Resource Type:
    Dissertation

  • Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

    Creator:
    Courter, Lauren A.
    Abstract:
    Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
    Resource Type:
    Dissertation
    Full Text:
    Abstract approved: _____________________________________________________________________ William M

  • In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

    Creator:
    Usenko, Crystal Y.
    Abstract:
    Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
    Resource Type:
    Masters Thesis

  • Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

    Creator:
    Shenvi, Swapna V.
    Abstract:
    Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
    Resource Type:
    Dissertation
    Full Text:
    like to thank my graduate committee members, Drs. William Baird, Balz Frei, Jeffrey Greenwood, and

  • Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

    Creator:
    Bajaj, Gaurav
    Abstract:
    EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
    Resource Type:
    Dissertation
    Full Text:
    (Condeelis and Taylor, 1977), cytokinesis (De Lozanne and Spudich, 1987), and neurite outgrowth (Wylie and

  • Influence of wetland landscape structure of shorebirds wintering in an agricultural valley

    Creator:
    Taft, Oriane Williams
    Abstract:
    Understanding how wetland birds use habitat is pivotal to developing successful and beneficial conservation strategies. Although it has been an ardent topic in forest research for some time, how species interact with the spatial patterning of habitat across a landscape (i.e., landscape structure) has been more or less neglected in...
    Resource Type:
    Dissertation
    Full Text:
    (University of Nevada-Reno), Dennis Peters (NRCS), William Robbins (OSU), Peter Sanzenbacher, Jeff Steiner

  • Prostate cancer prevention with broccoli : from cellular to human studies

    Creator:
    Clarke, John D.
    Abstract:
    Prostate cancer is the second leading cause of cancer related death in American men. Epidemiologic studies suggest that cruciferous vegetable intake may lower the risk for many cancers, including prostate and colon. Isothiocyanates (ITC) are phytochemicals derived from cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage that may...
    Resource Type:
    Dissertation
    Full Text:
    beautiful kids, William and Ashley, for their sweet innocence to remind me of the important things; my

  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
    Resource Type:
    Dissertation
    Full Text:
    AUTHORS I would like to acknowledge the efforts and expertise of Alan Taylor. He contributed a great

  • Utilization of lignocellulosic polysaccharides

    Creator:
    Fenske, John J.
    Abstract:
    Lignocellulosic biomass represents a vast supply of fermentable carbohydrates and functional aromatic compounds. Conversion of lignocellulosics to ethanol and other useful products would be of widespread economical and environmental benefit. Better understanding of the behavior of different lignicellulosic feedstocks in fermentation protocols as well as catalytic activities involved in lignocellulosic...
    Resource Type:
    Dissertation

  • A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

    Creator:
    Myzak, Melinda C.
    Abstract:
    Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
    Resource Type:
    Dissertation