Index Catalog // ScholarsArchive@OSU

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Creator:: Myzak, Melinda C.
Abstract:: Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Sulforaphane (SFN), a compound found at high levels in broccoli and broccoli sprouts, is a potent inducer of Phase 2 detoxification enzymes and inhibits tumorigenesis in animal models. SFN also has a...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Melinda C. Myzak for the

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Creator:: Scheri, Richard C.
Abstract:: Chlordecone belongs to the class of persistent organochlorine pesticides that are remarkably resistant to environmental degradation. Even though their use was banned in the United States in 1978, these compounds can still be detected in both humans and wildlife throughout the world. Previous work has shown that the pretreatment of...
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Richard C. Scheri for the degree of Doctor of Philosophy in Toxicology presented on May

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Creator:: Courter, Lauren A.
Abstract:: Human exposure to the carcinogenic polycyclic aromatic hydrocarbons (PAHs) benzo[a]pyrene (B[a]P) and dibenzo[a,l]pyrene (DB[a,l]P) is through environmental complex mixtures, such as urban dust particulate matter (UDPM) and diesel exhaust (DE), however the potency of these PAH within a mixture is not established. To determine the effect of these mixtures on...
Resource Type:: Dissertation
Full Text:: Abstract approved: _____________________________________________________________________ William M

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Creator:: Wise, Mitchell L.
Resource Type:: Dissertation
Full Text:: Abstract approved: William H. Gerwick A novel enzyme, polyenoic fatty acid isomerase, which catalyzes the

Influence of wetland landscape structure of shorebirds wintering in an agricultural valley

Creator:: Taft, Oriane Williams
Abstract:: Understanding how wetland birds use habitat is pivotal to developing successful and beneficial conservation strategies. Although it has been an ardent topic in forest research for some time, how species interact with the spatial patterning of habitat across a landscape (i.e., landscape structure) has been more or less neglected in...
Resource Type:: Dissertation
Full Text:: (University of Nevada-Reno), Dennis Peters (NRCS), William Robbins (OSU), Peter Sanzenbacher, Jeff Steiner

Consequences of coumaphos and Varroa destructor on drone honey bee sperm quantity

Creator:: Delaney, Deborah Anne
Abstract:: The number of drones and genetic diversity among drones are essential components to a well mated queen. Varroa destructor preferentially parasitizes drone brood, and is thought to be responsible for the loss of feral populations that once provided additional drones for honey bee mating areas. It is necessary to use...
Resource Type:: Masters Thesis
Full Text:: my graduate committee. I am grateful to Dr. William Winner, former head of the Environmental

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Creator:: Usenko, Crystal Y.
Abstract:: Due to their unique physical, chemical, and magnetic properties, nanomaterials have great potential for industrial development. There is a pressing need to develop rapid whole animal-based testing assays to assess the potential toxicity of engineered nanomaterials. To meet this challenge the embryonic zebrafish model was employed to determine the toxicity...
Resource Type:: Masters Thesis
Full Text:: nanomaterials induce toxicity. C60 is composed solely of C-C bonds, indicating a lack of innate

Studies on isoprenoid biosynthesis in Euglena gracilis

Creator:: Kim, Dojung
Abstract:: This dissertation describes studies of isoprenoid biosynthesis in the phytoflagellate Euglena gracilis. Elucidation of a novel isoprerioid pathway, the 2-Cmethyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known mevalonate (MVA) pathway, led to extensive exploration of the distribution of both pathways in a variety of organisms. To date, photosynthetic eukaryotes...
Resource Type:: Dissertation
Full Text:: , the 2-C- methyl-D-erythritol-4-phosphate (MEP) pathway, in addition to the generally known

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Creator:: Bajaj, Gaurav
Abstract:: EF-hand proteins are a conserved family of proteins that are modulated by divalent cations and regulate diverse cellular activities. In the present study we characterized the molecular determinants of myosin regulatory light chain (RLC) interaction with several subunits of the N-methyl-D-aspartate (NMDA)-type glutamate receptor. Myosin RLC is an EF-hand protein...
Resource Type:: Dissertation
Full Text:: the myosin RLC binding site to a 30-37 amino acid region of the C-termini of NR1 and NR2 subunits

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

Creator:: Shenvi, Swapna V.
Abstract:: Glutathione (GSH) is the predominant low molecular weight thiol antioxidant in liver tissue. GSH plays an important role in maintaining the intracellular thiol redox ratio as well as detoxification of electrophiles and xenobiotics. Aging leads to a significant decline (35%; P ≤ 0.05) in hepatocellular GSH levels. Using young (2-4...
Resource Type:: Dissertation
Full Text:: proteins, c-Jun, c-Fos and the histone acetyltransferase CREB-Binding Protein (CBP). In aging

ScholarsArchive@OSU

A novel mechanism of chemoprevention by sulforaphane : inhibition of histone deacetylase

Chlordecone pretreatment promoted subcellular distribution of scavenger receptor class B type II to murine hepatic microsomes ; mass spectrometry detected hepatic soluble cholesterol binding proteins and comparison of protein iTRAQ ratios using ESI QTOF and MALDI TOF/TOF

Environmental complex mixtures modify benzo[a]pyrene and dibenzo[a,l]pyrene-induced carcinogenesis

Biosynthesis and enzymology of conjugated polyenoic fatty acid production in macrophytic marine algae

Influence of wetland landscape structure of shorebirds wintering in an agricultural valley

Consequences of coumaphos and Varroa destructor on drone honey bee sperm quantity

In vivo assessment of nanomaterial-induced toxicity using embryonic zebrafish

Studies on isoprenoid biosynthesis in Euglena gracilis

Regulation of NMDA-type glutamate receptors and MDR1 by two members of the EF-hand protein family

Age-related alterations in transcriptional regulation of hepatic glutathione synthesis : remediation by R-alpha-lipoic acid

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