Index Catalog // ScholarsArchive@OSU

Developing the Zebrafish (Danio rerio) As a Model to Evaluate the Toxicity of Chlorinated and Non-Chlorinated Solvents

Creator:: Wenning, Matthew
Abstract:: Chlorinated and non-chlorinated solvents are used in a variety of industrial processes and as a consequence, they have become environmental contaminants as well. Because of this, they lead to both occupational and environmental exposures. Exposure to these compounds can potentially result in various forms of neurological damage with a wide...
Resource Type:: Undergraduate Thesis and Presentation

Preparation and modification of cellooligosaccharides

Creator:: Akpinar, Ozlem
Abstract:: Cellooligosaccharides are the reaction intermediates produced during the hydrolysis of cellulose to glucose. Hence, they have the same chemical structure as cellulose, just shorter chain lengths. Cellooligosaccharides up to DP eight are soluble in water. The soluble cellooligosaccharides can be used "as is" in the food industry as non-digestible oligosaccharides...
Resource Type:: Dissertation
Full Text:: like to thank all my committee, Dr. Gita Cherian, Dr. David E. Williams and Dr. James Kennedy, for

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts

Creator:: Leelasvatanakij, Leena
Resource Type:: Masters Thesis
Full Text:: , and Dr. David E. Williams, who gave their time to read my thesis and be present at my defense. Last

Pharmacokinetic analysis of antimicrobials and an anthelmintic agent in alpacas and llamas with theoretical applications

Creator:: Wattananat, Triporn
Abstract:: The pharmacokinetics of two antimicrobials were investigated in alpacas. Six healthy alpacas were each administered a single dose of 10 mg/kg of oxytetracycline by IV injection and IM injection. In addition, a single dose of 20 mg/kg of florfenicol by IV administration was given to alpacas in a separate study....
Resource Type:: Dissertation
Full Text:: . David E. Williams for their valuable time. Special thanks are also directed to Dr. Bradford B. Smith

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Creator:: Rosemond, Marie Victoire M.
Abstract:: Previous studies have shown that rainbow trout exposed to dieldrin via diet for 9 to 12 weeks increased biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500%. This was not explained by induction of the cytochrome P-450 (CYP) system involved in oxidative metabolism of these compounds. We hypothesized that...
Resource Type:: Masters Thesis
Full Text:: appreciation to the members of my graduate committee for their input and participation: Dr. David E. Williams

Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

Creator:: Barnhill, Melanie L.
Abstract:: Feeding rainbow trout 0.3-0.4 mg dieldrinlkg/d for 9-12 weeks stimulated the biliary excretion of a subsequent dose of [¹⁴C]dieldrin by 500% and [³H]7,12- dimethylbenz[a]anthracene (DMBA) by 240%. In vitro work demonstrated that this interaction occurred without induction of the cytochrome P450 system, or other hepatocellular proteins involved in metabolism. The...
Resource Type:: Masters Thesis
Full Text:: the members of my graduate committee for their input and participation: Dr. David E. Williams, Dr

Base inclinations for DNA in solutions and films as revealed by linear dichroism

Creator:: Kang, Hunseung
Resource Type:: Dissertation
Full Text:: . David E. Williams, and Dr. Malcolm Daniels, for their help and discussion in guiding my graduate

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Creator:: Chang, Yvonne
Abstract:: The environmental health science community recognizes polycyclic aromatic hydrocarbons (PAHs) as a re-emerging class of environmental pollutants due to their persistence and prominence in mixtures of concern. Due to their widespread distribution in the environment, exposure to PAHs often occur as complex chemical mixtures. Exposures are linked to numerous adverse...
Resource Type:: Dissertation
Full Text:: . Staci Simonich, Dr. David Williams, Dr. Barbara Taylor, and Dr. Molly Megraw for their contributions

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:: Thomas, Nicholas O.
Abstract:: Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...
Resource Type:: Dissertation
Full Text:: , surprisingly bawdy humor, and oh so many helping hands. Dr. Eric (E-bone) Smith for irreplaceable

Chlamydiae Enhance Self-Antigen Presentation in a Mechanism that is Dependent on Biosynthesis of Lipooligosaccharide

Creator:: Cram, Erik D.
Abstract:: Chlamydia is a genus of obligate intracellular bacteria that undergo a unique, biphasic developmental cycle. The infectious and metabolically inert Elementary Bodies (EBs) begin the cycle of infection by attaching and invading a host cells. Once inside, the EBs differentiate into the metabolically active, dividing Reticulate Bodies (RBs) within their...
Resource Type:: Dissertation
Full Text:: Freitag and David E. Williams have given me invaluable personal and technical guidance for which I am

ScholarsArchive@OSU

Developing the Zebrafish (Danio rerio) As a Model to Evaluate the Toxicity of Chlorinated and Non-Chlorinated Solvents

Preparation and modification of cellooligosaccharides

Comparison and optimization of chromatographic conditions for separation of cyclic dynorphin A analogues from linear byproducts

Pharmacokinetic analysis of antimicrobials and an anthelmintic agent in alpacas and llamas with theoretical applications

Dieldrin pretreatment does not induce hepatic microsomal and cytosolic epoxide hydrolase activities in rainbow trout (Oncorhyncus mykiss)

Dieldrin stimulates biliary excretion of [14 C] benzo[a]pyrene polar metabolites but does not change the metabolite profile in rainbow trout (Oncorhyncus mykiss)

Base inclinations for DNA in solutions and films as revealed by linear dichroism

Toxicogenomic Biomarkers Associated with PAH Carcinogenic Potential in a 3D in Vitro Bronchial Epithelial Model

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Chlamydiae Enhance Self-Antigen Presentation in a Mechanism that is Dependent on Biosynthesis of Lipooligosaccharide

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