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Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:

Sanchez, Karina M.

Abstract:

Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...

Resource Type:

Undergraduate Thesis

Full Text:

(NIFA) which is part of the US Department of Agriculture (USDA) and Dr. Fred Stevens’ OSU College of