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Filtering by: Creator Kuhl, Joseph C. Remove constraint Creator: Kuhl, Joseph C. Contributor Beilby, Pamela R. Remove constraint Contributor: Beilby, Pamela R.

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  • From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

    Creator:
    Meeuwsen, Joseph C.
    Abstract:
    Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
    Resource Type:
    Dissertation
    Full Text:
    Joseph C. Meeuwsen for the degree of Doctor of Philosophy in Molecular and Cellular Biology presented