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From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

Creator:

Meeuwsen, Joseph C.

Abstract:

Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...

Resource Type:

Dissertation

Full Text:

: _____________________________________________________________________ Joseph S. Beckman Altogether, this dissertation highlights the value of mass
Columbia River salmonid outmigration : McNary Dam passage and enhanced smolt quality : completion report, April 1, 1985

Creator:

Schreck, Carl B. and Li, Hiram W.

Abstract:

We evaluated the effects of the McNary Dam transportation system on emigrating fall and spring chinook smolts using physiological indices of stress (e.g., plasma cortisol, hepatic glycogen, leucocrit, interrenal cell nuclear diameter) and performance tests (e.g., saltwater challenge, secondary stress challenge, disease resistance). We also conducted controlled experiments in a...

Resource Type:

Technical Report

Full Text:

. . Experimental design, results, and discussion Stress and S-:-:imming Perfonnance . Experimental design