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Filtering by: Creator Koenen, Erik J. M. Contributor Brian Dolan Degree Level Bachelor's

Evaluation of a Monoclonal Antibody for Studying MHC Class I Antigen Presentation In-Vitro

Creator:

VanderHoek, Eden N.

Abstract:

Human epidermal growth factor receptor 2 (HER2), a member of the receptor tyrosine kinase (RTK) family, is frequently dysregulated in a variety of cancers. Overexpression of the receptor leads to increased cell proliferation and resistance to cell death due to downstream signaling effects. Proteasomal degradation of HER2 results in the...

Resource Type:

Honors College Thesis

Full Text:

(300 μM, 30 μM, 3 μM, 0 μM) for 30 minutes prior to staining with 1:500 or 1:1000 dilution of