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Importance of TLR2 and TLR4 signaling against M. abscessus infection of macrophages and use of mycobacteriophage genomics toward understanding some of the aspects of phage therapy

Creator:

Kapoor, Hannah A.

Abstract:

Mycobacterium abscessus (MAB) is an opportunistic pathogen responsible for infections in immunocompromised or immunosuppressed patients. Even with long-term treatment with multiple antibiotics, MAB pulmonary infections have high rates of treatment failure. Within the host, MAB is phagocytosed by key innate immune cells macrophages. The TLR2 and TLR4 are two critical...

Resource Type:

Honors College Thesis

Full Text:

attenuate MAB growth within mouse models to an extent (Le Moigne et al., 2020). It is known that