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Filtering by: Creator Calhoun, Jeannette A. Contributor Cassidy, Pamela B. Degree Level Doctoral

Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:

Carpenter, Evan L.

Abstract:

Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...

Resource Type:

Dissertation

Full Text:

., keratinocytes). However, melanocytes encounter a large burden of oxidative stress during this process, due to