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  • Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

    Creator:
    Lattier, Vera C.
    Abstract:
    Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...
    Resource Type:
    Dissertation
    Full Text:
    OF THE DISSERTATION OF Vera Chih-Ning Lattier for the degree of Doctor of Philosophy in Molecular

  • Vitamin E Protects Developmental Gene Expression and Metabolic Networks in Zebrafish Embryos

    Creator:
    Head, Brian A.
    Abstract:
    Vitamin E (VitE) is necessary for vertebrate embryonic development. VitE prevents lipid peroxidation (LPO), which requires detoxification by cellular antioxidant systems subsequently involving reducing power derived from energy metabolism. Thus, VitE protects metabolic networks in the developing embryo and the integrated gene expression networks compensating for and impaired by LPO-induced...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Brian A. Head for the degree of Doctor of Philosophy in Molecular and