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Filtering by: Creator Watson, Sawyer Contributor Danelishvili, Lia Degree Level Doctoral

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Creator:

Joseph, Jayanthi J.

Abstract:

To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...

Resource Type:

Dissertation

Full Text:

type I interferons (IFN-α and IFN-β) (Schoggins et al., 2014; Watson et al., 2015). Cytosolic DNA