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Filtering by: Creator Arp, Daniel J. Contributor Danelishvili, Lia

Characterization of Mycobacterium avium subsp. hominissuis Interactions with Host Macrophages and Multinucleated Giant Cells

Creator:

Joseph, Jayanthi J.

Abstract:

To examine the macrophage response to M. avium, I compared inflammasome and cytosolic sensor expression and activation. My result demonstrated that virulent strains of M. avium (A5 and 104) suppress IL-1β production and induce IFN-β production in macrophages. M. avium mutants deficient at DNA export in the biofilm exhibited reduced...

Resource Type:

Dissertation

Full Text:

ABSTRACT OF THE DISSERTATION OF Jayanthi J. Joseph for the degree of Doctor of Philosophy in
Bacterial and Host Factors Contributing to Mycobacterium avium subspecies paratuberculosis Persistent Infection

Creator:

Phillips, Ida L.

Abstract:

Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease, a chronic granulomatous enteritis that plagues domestic and wild ruminants globally. During the silent stages of Johne’s disease, infected animals intermittently shed bacteria for years prior to clinical diagnosis during advanced disease stages. This strategy allows MAP to...

Resource Type:

Dissertation

Full Text:

colostrum (R. J. Whittington et al.). Neonates should be bottle-fed pasteurized colostrum (Stabel). Milk
Mycobacterium abscessus genetic determinants associated with intrinsic resistance to antibiotics

Creator:

Gorzynski, Mylene

Abstract:

M. abscessus subsp. abscessus is a nontuberculous mycobacterium causing pulmonary infections in immunocompromised patients. The treatment of MAB infections is challenging due to its natural resistance to most antibiotics. To identify MAB genetic factors that are involved in mechanisms of the antibiotic tolerance, we screened the library of 2,000 gene...

Resource Type:

Honors College Thesis