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Filtering by: Contributor Freitag, Michael Creator Jackson, Kendra K. Degree Name Honors Bachelor of Science (H.B.S.)

The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creator:

Jackson, Kendra K.

Abstract:

PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...

Resource Type:

Honors College Thesis