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Filtering by: Creator Chen, Peter Y. S. Remove constraint Creator: Chen, Peter Y. S. Contributor Freitag, Michael Remove constraint Contributor: Freitag, Michael Degree Level Bachelor's Remove constraint Degree Level: Bachelor's

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  • A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

    Creator:
    Geisler, Mark S.
    Abstract:
    Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...
    Resource Type:
    Honors College Thesis
    Full Text:
    ). In S. pombe, Swi6 (HP1) is required for recruitment of the cohesion complex for segregation in

  • The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

    Creator:
    Jackson, Kendra K.
    Abstract:
    PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...
    Resource Type:
    Honors College Thesis
    Full Text:
    overnight expression at 18◦C after induction with 0.1mM IPTG. Fractions “S” and “P” refer to supernatant