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The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creator:

Jackson, Kendra K.

Abstract:

PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...

Resource Type:

Honors College Thesis

Full Text:

minutes using the Beckman J-6B in ALS 2110. Pellets were stored at -20°C for up to 2 weeks. Pellets were
Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Creator:

Park, Catherine

Abstract:

The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...

Resource Type:

Honors College Thesis

Full Text:

and J show validation for pCP14. Some of the bands are not clear on image, but were seen in person at
A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:

Geisler, Mark S.

Abstract:

Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...

Resource Type:

Honors College Thesis