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Filtering by: Creator Rosegrant, Mark W. Contributor Freitag, Michael Non-Academic Affiliation Oregon State University. Honors College

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:

Geisler, Mark S.

Abstract:

Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...

Resource Type:

Honors College Thesis

Full Text:

Centromere Maintenance and Gene Silencing by Mark Stephen Geisler A
The role of the putative transcription factor DIS10 in PRC2-mediated gene silencing

Creator:

Jackson, Kendra K.

Abstract:

PRC2 (Polycomb Repressive Complex 2) mediated gene silencing plays an important role in cell differentiation, stem cell plasticity, and tumor suppression. In fungi, it is also involved in pathogenicity. The catalytic subunit, KMT6, trimethylates lysine 27 on histone h3 (H3K27me3) at loci targeted for silencing. In animals, PRC1 and PRC2...

Resource Type:

Honors College Thesis

Full Text:

mM DTT, 8.0% w/v SDS, 6 mM bromophenol blue, 4.3 M glycerol) was added to the supernatant and