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Filtering by: Creator Friedman, Steven Contributor Freitag, Michael

A Panel of Histone H3 Mutations to Investigate Centromere Maintenance and Gene Silencing

Creator:

Geisler, Mark S.

Abstract:

Histones, as part of nucleosomes, are responsible for DNA packaging in chromosomes. They also affect DNA expression by a multitude of post-translational modifications, especially prevalent on the amino terminus of histones. Co-activator protein complexes “write”, “read”, or “erase” histone modifications, and in balance determine which sections of DNA are free...

Resource Type:

Honors College Thesis

Full Text:

, Madison Esposito, Steven Friedman, Rodrigo Gonçalves, and Michael Freitag conceived and designed the
Generation of expression plasmids to study the function of the PRC2 subunit Suz12 in Fusarium graminearum

Creator:

Park, Catherine

Abstract:

The Polycomb Repressive Complex 2 (PRC2) catalyzes genome transcription repression through the methylation of lysine residue 27 in the amino terminal region of histone 3 (H3K27me1/2/3) [2], [7]. PRC2 is made up of three highly conserved core subunits: Kmt6, Eed, and Suz12. Accurate distribution of PRC2 is essential for proper...

Resource Type:

Honors College Thesis

Full Text:

Gene Clusters.” PLoS Genetics 9, no. 10 (October 2013): e1003916. (5) Erlendson, Allyson A., Steven