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Filtering by: Creator Oliveira, Leandro G. Remove constraint Creator: Oliveira, Leandro G. Contributor Garcia Jaramillo, Manuel Remove constraint Contributor: Garcia Jaramillo, Manuel

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  • Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

    Creator:
    Spooner, Melinda H.
    Abstract:
    Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...
    Resource Type:
    Dissertation
    Full Text:
    use a WD containing 40% fat, 43% carbohydrate 17% protein, and 1.5 mg/g of diet to induce NASH. Mice

  • Harnessing Heterogeneity in Human Gut Microbiome Data

    Creator:
    Tataru, Christine
    Abstract:
    The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
    Resource Type:
    Dissertation
    Full Text:
    implicated in energy harvest, fat storage, and obesity by way of G protein coupled receptors (GPCRs) and G