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Filtering by: Creator Jacobs, Dakota Contributor Giebultowicz, Jadwiga M.

Generation of Kisspeptin Cell Lines to Investigate the Sex Steroid-Mediated Initiation of Puberty

Creator:

Jacobs, Dakota C.

Abstract:

Mammalian female reproduction requires preovulatory surges of gonadotropin-releasing hormone (GnRH) from neurons in the preoptic area (POA) of the hypothalamus, initiated by elevated estradiol (E₂). Rising E₂ activates a subset ofsexually dimorphic Kisspeptin neurons in the female, located in the anteroventralperiventricular nuclei (AVPV). Conversely, E₂ negative feedback is mediated by...

Resource Type:

Presentation and Undergraduate Thesis