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Filtering by: Creator Evans, Lynn B. Contributor Hendrix, David

Machine Learning Methods for the Discovery and Analysis of MicroRNAs

Creator:

Bell, Jimmy D.

Abstract:

MicroRNAs are a highly conserved class of small endogenous RNA, about ~22nt in length, involved in post-transcriptional gene silencing and have prominent roles in disease and development. Though the process of microRNA discovery was once an arduous task, the advent of high throughput sequencing technology has resulted in novel microRNAs...

Resource Type:

Masters Thesis

Full Text:

removed (Figure 2.4a-b). In some cases, features gained the importance after removal of their correlated
Gene regulatory mechanisms of the lncRNA Fendrr

Creator:

Koehler, Monika

Abstract:

Embryonic development, where organs and major structures begin to develop, requires precise coordination of numerous gene regulatory pathways. Fendrr is an long non-coding RNA (lncRNA) that plays a role in regulating gene expression in mesodermal tissues during early embryonic development in mouse. The lateral plate mesoderm (LPM) is an earlier...

Resource Type:

Presentation and Undergraduate Thesis

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ENSMUSG00000015619 Gata3 GATA binding protein 3 ENSMUSG00000052837 Junb Jun-B oncogene ENSMUSG00000034402 Kcnh5
Position-Dependent Codon Usage Bias in the Human Transcriptome

Creator:

Subramanian, Kaavya

Abstract:

All life depends on the reliable translation of RNA to protein according to complex interactions between translation machinery and RNA sequence features. While ribosomal occupancy and codon frequencies vary across coding regions, well-established metrics for computing coding potential of RNA do not capture such positional dependence. Here, we investigate position-dependent...

Resource Type:

Honors College Thesis

Full Text:

first 300 nt of all coding regions. Codons have been shuffled. B. Z-score heatmap based on amino acid