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Filtering by: Contributor Iversen, Patrick Date 2016 Non-Academic Affiliation Oregon State University. Undergraduate Research, Scholarship, and the Arts (URSA)

Alternative Exon 3 Inclusion in the Vitamin D Receptor (VDR) Modulates Transcriptional Activity for Target Genes in a Ligand-Independent Manner

Creator:

Cameron, Alex N., Annalora, Andrew, and Marcus, Craig

Abstract:

Xenobiotic exposures may induce alternative splicing in the pre-mRNA of nuclear hormone receptor (NHR) genes, yielding unpredictable patterns of gene expression that may promote adverse drug events and promote environmental disease. Informed by observations in the androgen receptor (AR; class I NHR), whereby alternatively-spliced AR transcripts induce ligand-independent hormone signaling...

Resource Type:

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ScholarsArchive@OSU

Alternative Exon 3 Inclusion in the Vitamin D Receptor (VDR) Modulates Transcriptional Activity for Target Genes in a Ligand-Independent Manner

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