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Filtering by: Creator McKinnon, P. F. Remove constraint Creator: McKinnon, P. F. Contributor Jiang, Yuan Remove constraint Contributor: Jiang, Yuan Resource Type Dissertation Remove constraint Resource Type: Dissertation

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  • Regularization-Based Data Integration and Its Application to Genome-Wide Association Studies

    Creator:
    Li, Kai
    Abstract:
    In genome-wide association studies, it is often challenging to have consistent findings from independent studies. This "lack of reproducibility" issue is partially caused by the relatively small sample size compared to the number of genetic markers in every single study. Therefore, researchers have developed statistical methods to integrate multiple studies...
    Resource Type:
    Dissertation
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    distribution), which is the theoretical basis of F -test (or t-test) for testing significance of coefficients

  • Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

    Creator:
    Song, Zifeng
    Abstract:
    Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
    Resource Type:
    Dissertation
    Full Text:
    Page Figure 4. 2 Volcano plots illustrating the distributions of p-values and fold changes of all

  • Microbial Network Recovery by Compositional Graphical Lasso Under Additive Log-Ratio Transformation

    Creator:
    Tian, Chuan
    Abstract:
    The interactions between microbial taxa have been under great research interest in the sci- ence community given the microbiome data deluge. Several methods have been proposed to model and estimate the conditional dependency between microbial taxa for their interac- tions, in order to eliminate spurious correlation detections. However, these methods...
    Resource Type:
    Dissertation

  • Impacts of microbial chemical interactions on marine plankton physiology

    Creator:
    Moore, Eric R.
    Abstract:
    The bioavailability of chemical compounds in the marine environment fundamentally influences the growth and physiology of microorganisms. Organic and inorganic chemicals that are produced by some marine plankton can be consumed by other plankton for energy production, growth, or to initiate essential physiological processes. Cultures of the diatom Thalassiosira pseudonana,...
    Resource Type:
    Dissertation
    Full Text:
    glyceraldehyde-3-phosphate (G-3-P)………………………………………….....99 121 122 4.1 The life cycle of a centric diatom