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Western Diet-Induced Nonalcoholic Steatohepatitis (NASH): The Impact of Time on the Onset and Remission of Disease

Creator:

Spooner, Melinda H.

Abstract:

Nonalcoholic fatty liver disease (NAFLD) is characterized by an accumulation of neutral lipids in the form of triglycerides and cholesterol esters accounting for >5% of liver weight. Excess neutral lipids accumulate in large lipid droplets, i.e., macrosteatosis, displacing the nucleus of cells. Current theory suggests neutral lipid accumulation is the...

Resource Type:

Dissertation

Full Text:

endeavors of lifelong learning. Next, my committee members Dr. Emily Ho, Dr. Natalia Shulzhenko, Dr
Machine Learning Methods for the Discovery and Analysis of MicroRNAs

Creator:

Bell, Jimmy D.

Abstract:

MicroRNAs are a highly conserved class of small endogenous RNA, about ~22nt in length, involved in post-transcriptional gene silencing and have prominent roles in disease and development. Though the process of microRNA discovery was once an arduous task, the advent of high throughput sequencing technology has resulted in novel microRNAs...

Resource Type:

Masters Thesis