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Immunomodulatory Actions of Bovine Whey Protein Isolates, Glycomacropeptide, and Their Digests: Insights from Macrophage and Human Studies

Creator:

Olsen, Wyatt

Abstract:

Whey protein isolate (WPI) and glycomacropeptide (GMP) have shown potential immunomodulatory properties. In this study, we investigated their effects on pro-inflammatory cytokine secretion using both in vitro and in vivo models. In LPS-stimulated THP-1-derived macrophages, digested WPI and GMP reduced cytokine expression, while whole GMP increased secretion. The in human...

Resource Type:

Masters Thesis

Full Text:

within the glycosylated form of GMP: disaccharides (N-acetyl galactosamine and galactose, GalNAcGal
Effects of Whey Protein Consumption on Inflammatory Biomarker Levels in Healthy Older Adults

Creator:

Adler, Samuel

Abstract:

Whey protein’s potential for bioactivity is well documented, but there is disagreement on the extent to which it may modulate the immune system towards decreased inflammation. Decreased inflammation is generally perceived as a beneficial bioactivity in foods as excessive chronic inflammation is linked to morbidity and mortality. This thesis first...

Resource Type:

Masters Thesis

Full Text:

(SCFAs) Stress-activated protein kinase/c-Jun N-terminal kinases (SAPK/JNK) Superoxide dismutase-2