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Filtering by: Creator Kawula, Steven P. Contributor Stevens, Jan F. Degree Level Bachelor's

Detection and Identification of Acetaminophen (Tylenol) Metabolites using Liquid Chromatography High Resolution Mass Spectrometry (LC-HRMS/MS) Analysis

Creator:

Sanchez, Karina M.

Abstract:

Acetaminophen (APAP) is a commonly used analgesic and antipyretic drug that can cause liver injury, liver necrosis, and liver failure. APAP-induced liver failure (AILF) is associated with depletion of glutathione and the increased formation of APAP protein adducts from the toxic NAPQI metabolite. There is a hypothesized detoxifying pathway where...

Resource Type:

Undergraduate Thesis

Full Text:

pathway where vitamin C ascorbylates and conjugates the hepatotoxic metabolite N-acetyl-p- benzoquinone
Using Mass Spectrometry to Trace Polyphenols in Human Urine

Creator:

Carrillo, Crystal V.

Abstract:

Diet History Questionnaires (DHQ) can only provide general information about a person’s nutritional intake. It is unable to cluster groups of people based on diets or lifestyles, nor identify specific foods that may play a role in disease prevention. The aim of this study was to validate the use of...

Resource Type:

Presentation and Undergraduate Thesis

Full Text:

with DHQ, the strongest correlation value (r >.60, P-value<0.05) was measured for