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Filtering by: Creator Choi, Chang-Ho Contributor Stevens, Jan F. Degree Name Doctor of Philosophy (Ph.D.)

Homeodomain Transcription Factor Pitx2 is Required for Muscle Maintenance and Energy Homeostasis

Creator:

Lattier, Vera C.

Abstract:

Skeletal muscle, the largest organ in the body in mass, is composed by 600 specialized muscles in humans with unique biochemical, physiological and metabolic identities. Skeletal muscles control body movement, locomotion, and nutrient balance. Muscle formation requires precisely orchestrated environmental signals and regulatory gene networks in time and space. Gene...

Resource Type:

Dissertation

Full Text:

Chang (aka Vera Chih-Ning Lattier) and Chrissa Kioussi
Regulation of Redox Homeostasis in Skin Cells for the Prevention of UV-Induced Stress and Treatment of Melanoma

Creator:

Carpenter, Evan L.

Abstract:

Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...

Resource Type:

Dissertation

Full Text:

, nicotinamide adenine dinucleotide phosphate (NADPH): quinone oxidoreductase 1 (NQO1), heme oxygenase 1 (HO-1