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Mycobacterium abscessus genetic determinants associated with intrinsic resistance to antibiotics

Creator:

Gorzynski, Mylene

Abstract:

M. abscessus subsp. abscessus is a nontuberculous mycobacterium causing pulmonary infections in immunocompromised patients. The treatment of MAB infections is challenging due to its natural resistance to most antibiotics. To identify MAB genetic factors that are involved in mechanisms of the antibiotic tolerance, we screened the library of 2,000 gene...

Resource Type:

Honors College Thesis

Full Text:

was used: change (n-fold) = , where ΔCT is CT (target) − CT (16S) and Δ(ΔCT) is ΔCT (experimental
Exploration of the Phage Adsorption Mechanism in Mycobacterium abscessus Toward Improving the Efficacy of Current Antibiotics

Creator:

Gorzynski, Mylène

Abstract:

Background: Mycobacterium abscessus (MAB) is a rapidly growing opportunistic pathogen that causes infections in immunocompromised patients. The highly impermeable cell wall and surface transport systems are major contributing factors to MAB intrinsic resistance, influencing the efficacy of bactericidal antibiotics. Phages are promising alternatives to antibiotics and have been used in...

Resource Type:

Masters Thesis

Full Text:

. CONTRIBUTION OF AUTHORS Mylène Gorzynski contributed to experimental design, conducted experiments