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Filtering by: Committee Member Ho, P. Shing Remove constraint Committee Member: Ho, P. Shing Contributor sim Hare, Michael C. Remove constraint Contributor sim: Hare, Michael C.

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  • From ALS to Antibodies: New Techniques in Mass Spectrometry-Based Proteoform Characterization

    Creator:
    Meeuwsen, Joseph C.
    Abstract:
    Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics. Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
    Resource Type:
    Dissertation
    Full Text:
    , role modeling, and assistance. To my committee members – Drs. Emily Ho, Andy Karplus, Kathy