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Filtering by: Creator Choi, Chang-Ho Remove constraint Creator: Choi, Chang-Ho Creator Abdullah, Alanzi R. Remove constraint Creator: Abdullah, Alanzi R. Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.)

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  • Regulation of Secondary Metabolite Production in Streptomyces

    Creator:
    Abdullah, Alanzi R.
    Abstract:
    Among the myriad of natural products are pseudosugar-containing secondary metabolites, e.g., the C7-pseudosugar-containing oligosaccharide acarbose, the C6- pseudosugar-containing aminoglycoside antibiotics, and the five-membered ring pseudosugar-containing antibiotic pactamycin. The C7-pseudosugars are normally derived from sedoheptulose 7-phosphate catalyzed by a family of enzymes called sedoheptulose 7-phosphate cyclases (SH7PCs). This family of enzymes...
    Resource Type:
    Dissertation
    Full Text:
    of which are cyclization products of sedoheptulose 7-phosphate (Choi et al., 2008) (Dong et al