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Filtering by: Creator Chou, Chia-Fu Creator Alani, Adam W. G. Language English [eng]

Inhibitory Effect of Paclitaxel and Rapamycin Individual and Dual Drug-Loaded Polymeric Micelles in the Angiogenic Cascade

Creator:

Mishra, Gyan P., Nguyen, Duc, and Alani, Adam W. G.

Abstract:

Angiogenesis is an essential process for disease progression in many solid tumors. There are several major cascade events in the angiogenic process that can be targeted to inhibit new blood vessel formation in the tumor tissue. The purpose of this work is to evaluate the inhibitory effect of paclitaxel (PTX)...

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analysis. This software is based on Chou and Talay median-effect method34, in which the median-effect
Antiangiogenic Effect of Docetaxel and Everolimus as Individual and Dual-Drug-Loaded Micellar Nanocarriers

Creator:

Mishra, Gyan P., Doddapaneni, Bhuvana Shyam, Nguyen, Duc, and Alani, Adam W. G.

Abstract:

PURPOSE: The in vitro inhibitory effect of Docetaxel (DTX) and Everolimus (EVR) alone and together in poly(ethylene glycol)-block-poly(D,L-lactic acid) (PEG-b-PLA) nanocarriers on angiogenic processes and acute toxicity in mice was evaluated. METHODS: PEG-b-PLA DTX and/or EVR nanocarriers were characterized for size, drug loading, stability, and drug release. Cell proliferation, tubule...

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Chou and Talay median-effect method in which the median-effect 1 2 3 4 5 6 7 8 9 10