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Filtering by: Creator Kropp, Jaclyn D. Creator Alluin, Jessica Resource Type Article

Interplay between HIV-1 infection and host microRNAs

Creator:

Sun, Guihua, Li, Haitang, Wu, Xiwei, Covarrubias, Maricela, Scherer, Lisa, Meinking, Keith, Luk, Brian, Chomchan, Pritsana, Alluin, Jessica, Gombart, Adrian F., and Rossi, John J.

Abstract:

Using microRNA array analyses of in vitro HIV-1-infected CD4(+) cells, we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro. While microRNA-223 levels were significantly enriched in HIV-1-infected CD4(superscript+)CD8(superscript-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the...

Resource Type:

Article

Full Text:

the target region (siCheck2.2-C, D, E, F and siCheck3.2/4.2-A, B in Figure 2. MiR-29 and miR-223