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Filtering by: Creator Bair, Russell Creator Baarda, Benjamin I.

Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease

Creator:

Baarda, Benjamin I. and Sikora, Aleksandra E.

Abstract:

Neisseria gonorrhoeae is an exquisitely adapted, strictly human pathogen and the causative agent of the sexually transmitted infection gonorrhea. This ancient human disease remains a serious problem, occurring at high incidence globally and having a major impact on reproductive and neonatal health. N. gonorrhoeae is rapidly evolving into a superbug...

Resource Type:

Article
Proteomics-driven Antigen Discovery for Development of Vaccines Against Gonorrhea

Creator:

Zielke, Ryszard A., Wierzbicki, Igor H., Baarda, Benjamin I., Gafken, Philip R., Soge, Olusegun O., Holmes, King K., Jerse, Ann E., Unemo, Magnus, and Sikora, Aleksandra E.

Abstract:

Expanding efforts to develop preventive gonorrhea vaccines is critical because of the dire possibility of untreatable gonococcal infections. Reverse vaccinology, which includes genome and proteome mining, has proven very successful in the discovery of vaccine candidates against many pathogenic bacteria. However, progress with this approach for a gonorrhea vaccine remains...

Resource Type:

Article
Deciphering the Function of New Gonorrhea Vaccine Candidates in Cell Envelope Homeostasis

Creator:

Baarda, Benjamin I.

Abstract:

Neisseria gonorrhoeae is the sexually transmitted pathogen responsible for millions of cases of gonorrhea worldwide each year. Rapidly-spreading antibiotic resistance is diminishing the ability to effectively treat a disease with significant consequences to female and male reproductive health, as well as to neonatal well-being. A protective vaccine has the potential...

Resource Type:

Dissertation

Full Text:

transforming growth factor (TGF)-b and IL-10 (Liu and Russell, 2011; Liu et al., 2012; Liu et al., 2014