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Identification of Chemical Inhibitors of β-Catenin-Driven Liver Tumorigenesis in Zebrafish

Creator:

Evason, Kimberley J., Francisco, Macrina T., Juric, Vladislava, Balakrishnan, Sanjeev, del Pilar Lopez Pazmino, Maria, Gordan, John D., Kakar, Sanjay, Spitsbergen, Jan, Goga, Andrei, and Stainier, Didier Y. R.

Abstract:

Hepatocellular carcinoma (HCC) is one of the most lethal human cancers. The search for targeted treatments has been hampered by the lack of relevant animal models for the genetically diverse subsets of HCC, including the 20-40% of HCCs that are defined by activating mutations in the gene encoding β-catenin. To...

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Article

Full Text:

[11] and H-Ras co-expression[12], activated β-catenin is not sufficient to induce HCC in mice[6,12,13