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Filtering by: Creator Glavan, John Creator Batista, Pedro J.

Distinct Argonaute-mediated 22G-RNA pathways direct genome surveillance in the C. elegans germline

Creator:

Gu, Weifeng, Shirayama, Masaki, Conte Jr., Darryl, Vasale, Jessica, Batista, Pedro J., Claycomb, Julie M., Moresco, James J., Youngman, Elaine, Keys, Jennifer, Stoltz, Matthew J., Chen, Chun-Cheih G., Chaves, Daniel A., Duan, Shenghua E., Kasschau, Krisitin D., Fahlgren, Noah, Yates III, John R., Mitani, Shohei, Carrington, James C., and Mello, Craig C.

Abstract:

Endogenous small RNAs (endo-siRNAs) interact with Argonaute (AGO) proteins to mediate sequence-specific regulation of diverse biological processes. Here, we combine deep-sequencing and genetic approaches to explore the biogenesis and function of endo-siRNAs in C. elegans. We describe conditional alleles of the dicer-related helicase, drh-3, that abrogate both RNA interference and...

Resource Type:

Article

Full Text:

, Noah Falgren6, John R. Yates III4, Shohei Mitani7, James C. Carrington6, and Craig C. Mello1,2