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Filtering by: DOI 10.1172/JCI62070 Creator Beckman, Joseph S.

Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Creator:

Trias, Emiliano, Beilby, Pamela R., Kovacs, Mariangeles, Ibarburu, Sofia, Varela, Valentina, Barreto-Nunez, Romina, Bradford, Samuel C., Beckman, Joseph S., and Barbeito, Luis

Abstract:

Age is a recognized risk factor for amyotrophic lateral sclerosis (ALS), a paralytic disease characterized by progressive loss of motor neurons and neuroinflammation. A hallmark of aging is the accumulation of senescent cells. Yet, the pathogenic role of cellular senescence in ALS remains poorly understood. In rats bearing the ALS-linked...

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Article
Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

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Trias, Emiliano, Díaz-Amarilla, Pablo, Olivera-Bravo, Silvia, Isasi, Eugenia, Drechsel, Derek A., Lopez, Nathan, Bradford, C. Samuel, Ireton, Kyle E., Beckman, Joseph S., and Barbeito, Luis

Abstract:

Microglia and reactive astrocytes accumulate in the spinal cord of rats expressing the Amyotrophic lateral sclerosis (ALS)-linked SOD1ᴳ⁹³ᴬ mutation. We previously reported that the rapid progression of paralysis in ALS rats is associated with the appearance of prolifer- ative astrocyte-like cells that surround motor neurons. These cells, designated as Aberrant...

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Article

Full Text:

. 119, 13–15. doi: 10.1172/JCI38096 Barbeito, L. H., Pehar, M., Cassina, P., Vargas, M. R., Peluffo, H

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Emergence of Microglia Bearing Senescence Markers During Paralysis Progression in a Rat Model of Inherited ALS

Phenotypic transition of microglia into astrocyte-like cells associated with disease onset in a model of inherited ALS

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