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Filtering by: DOI 10.1172/JCI62070 Creator Bermudez, Luiz E.

Mycobacterium avium Possesses Extracellular DNA that Contributes to Biofilm Formation, Structural Integrity, and Tolerance to Antibiotics

Creator:

Rose, Sasha J., Babrak, Lmar M., and Bermudez, Luiz E.

Abstract:

Mycobacterium avium subsp. hominissuis is an opportunistic pathogen that is associated with biofilm-related infections of the respiratory tract and is difficult to treat. In recent years, extracellular DNA (eDNA) has been found to be a major component of bacterial biofilms, including many pathogens involved in biofilm-associated infections. To date, eDNA...

Resource Type:

Article
Mycobacterium tuberculosis Alters the Metalloprotease Activity of the COP9 Signalosome

Creator:

Danelishvili, Lia, Babrak, Lmar, Rose, Sasha J., Everman, Jamie, and Bermudez, Luiz E.

Abstract:

Inhibition of apoptotic death of macrophages by Mycobacterium tuberculosis represents an important mechanism of virulence that results in pathogen survival both in vitro and in vivo. To identify M. tuberculosis virulence determinants involved in the modulation of apoptosis, we previously screened a transposon bank of mutants in human macrophages, and...

Resource Type:

Article

Full Text:

mutant of Mycobacterium tuberculosis. J. Clin. Invest. 117: 2279 –2288. http://dx.doi.org/10.1172