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BissonWilliamEnvironMoleToxAdaptationHumanArylSuppInfo.pdf

Creator:: Hubbard, Troy D., Murray, Iain A, Bisson, William H., and et al.
Abstract:: Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Full Text:: microbiota-derived indoles’ Troy D. Hubbard, Iain A. Murray, William H. Bisson, Tejas S. Lahoti, Krishne

BissonWilliamEnvironMoleToxAdaptationHumanAryl.pdf

Creator:: Hubbard, Troy D., Murray, Iain A, Bisson, William H., and et al.
Abstract:: Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Full Text:: receptor to sense microbiota-derived indoles Troy D. Hubbard1,2, Iain A. Murray2, William H. Bisson3

Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions

Creator:: Kravchenko, Julia, Corsini, Emanuela, Williams, Marc A., Bisson, William H., Decker, William, Manjili, H. Masoud, Otsuki, Takemi, Sing, Neetu, Al-Mulla, Faha, Al-Temaimi, Rabeah, Amedei, Amedeo, Colacci, Anna Maria, Vaccari, Monica, Mondello, Chiara, Scovassi, A. Ivana, Raju, Jayadev, Hamid, Roslida A., Memeo, Lorenzo, Forte, Stefano, Roy, Rabindra, Woodrick, Jordan, Salem, Hosni K., Ryan, Elizabeth P., Brown, Dustin G., Bisson, william H., Lowe, Leroy, and Lyerly, H. Kim
Abstract:: An increasing number of studies suggest an important role of host immunity as a barrier to tumor formation and progression. Complex mechanisms and multiple pathways are involved in evading innate and adaptive immune responses, with a broad spectrum of chemicals displaying the potential to adversely influence immunosurveillance. The evaluation of...
Resource Type:: Article
Full Text:: , J., Corsini, E., Williams, M. A., Decker, W., Manjili, M. H., Otsuki, T., ... & Lyerly, H. K. (2015

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Creator:: Hubbard, Troy D., Murray, Iain A, Bisson, William H., Lahoti, Tejas S., Gowda, Krishne, Amin, Shantu G., Patterson, Andrew D., and Perdew, Gary H.
Abstract:: Ligand activation of the aryl hydrocarbon (AHR) has profound effects upon the immunological status of the gastrointestinal tract, establishing and maintaining signaling networks, which facilitate host-microbe homeostasis at the mucosal interface. However, the identity of the ligand(s) responsible for such AHR-mediated activation within the gut remains to be firmly established....
Resource Type:: Article

Environmental immune disruptors, inflammation and cancer risk

Creator:: Thompson, Patricia A., Khatami, Mahin, Baglole, Carolyn J., Jun Sun,, Harris, Shelley A., Moon, Eun-Yi, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Brown, Dustin G., Colacci, Annamaria, Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Hamid, Roslida A., Lowe, Leroy, Guarnieri, Tiziana, and Bisson, William H.
Abstract:: An emerging area in environmental toxicology is the role that chemicals and chemical mixtures have on the cells of the human immune system. This is an important area of research that has been most widely pursued in relation to autoimmune diseases and allergy/asthma as opposed to cancer causation. This is...
Resource Type:: Article
Full Text:: cancer risk Thompson, P. A., Khatami, M., Baglole, C. J., Sun, J., Harris, S., Moon, E. Y

Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

Creator:: Robey, R. Brooks, Weisz, Judith, Kuemmerle, Nancy B., Salzberg, Anna C., Berg, Arthur, Brown, Dustin G., Kubik, Laura, Palorini, Roberta, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Colacci, Anna Maria, Mondello, Chiara, Raju, Jayadev, Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Amedei, Amedeo, Hamid, Roslida A., Williams, Graeme P., Lowe, Leroy, Meyer, Joel, Martin, Francis L., Bisson, William H., Chiaradonna, Ferdinando, and Ryan, Elizabeth P.
Abstract:: Environmental contributions to cancer development are widely accepted, but only a fraction of all pertinent exposures have probably been identified. Traditional toxicological approaches to the problem have largely focused on the effects of individual agents at singular endpoints. As such, they have incompletely addressed both the pro-carcinogenic contributions of environmentally...
Resource Type:: Article

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

Creator:: Hu, Zhiwei, Brooks, Samira A., Dormoy, Valérian, Hsu, Chia-Wen, Hsu, Hsue-Yin, Lin, Liang-Tzung, Massfelder, Thierry, Rathmell, W. Kimryn, Xia, Menghang, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Brown, Dustin G., Prudhomme, Kalan R., Colacci, Annamaria, Hamid, Roslida A., Mondello, Chiara, Raju, Jayadev, Ryan, Elizabeth P., Woodrick, Jordan, Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Roy, Rabindra, Forte, Stefano, Memeo, Lorenzo, Salem, Hosni K., Lowe, Leroy, Jensen, Lasse, Bisson, William H., and Kleinstreuer, Nicole
Abstract:: One of the important ‘hallmarks’ of cancer is angiogenesis, which is the process of formation of new blood vessels that are necessary for tumor expansion, invasion and metastasis. Under normal physiological conditions, angiogenesis is well balanced and controlled by endogenous proangiogenic factors and antiangiogenic factors. However, factors produced by cancer...
Resource Type:: Article
Full Text:: , S. A., Dormoy, V., Hsu, C. W., Hsu, H. Y., Lin, L. T., ... & Kleinstreuer, N. (2015). Assessing the

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Creator:: Nahta, Rita, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Andrade-Vieira, Rafaela, Bay, Sarah N., Brown, Dustin G., Calaf, Gloria M., Castellino, Robert C., Cohen-Solal, Karine A., Colacci, Annamaria, Cruickshanks, Nichola, Dent, Paul, Di Fiore, Riccardo, Forte, Stefano, Goldberg, Gary S., Hamid, Roslida A., Krishnan, Harini, Laird, Dale W., Lasfar, Ahmed, Marignani, Paola A., Memeo, Lorenzo, Mondello, Chiara, Naus, Christian C., Ponce-Cusi, Richard, Raju, Jayadev, Roy, Debasish, Roy, Rabindra, Ryan, Elizabeth P., Salem, Hosni K., Scovassi, A. Ivana, Singh, Neetu, Vaccari, Monica, Vento, Renza, Vondráček, Jan, Wade, Mark, Woodrick, Jordan, and Bisson, William H.
Abstract:: As part of the Halifax Project, this review brings attention to the potential effects of environmental chemicals on important molecular and cellular regulators of the cancer hallmark of evading growth suppression. Specifically, we review the mechanisms by which cancer cells escape the growth-inhibitory signals of p53, retinoblastoma protein, transforming growth...
Resource Type:: Article
Full Text:: Nahta, R., Al-Mulla, F., Al-Temaimi, R., Amedei , A., Andrade-Vieira, R., Bay, S. ... & Bisson, W. H

Disruptive chemicals, senescence and immortality

Creator:: Carnero, Amancio, Blanco-Aparicio, Carmen, Kondoh, Hiroshi, Lleonart, Matilde E., Martinez-Leal, Juan Fernando, Mondello, Chiara, Scovassi, A. Ivana, Bisson, William H., Amedei, Amedeo, Roy, Rabindra, Woodrick, Jordan, Colacci, Annamaria, Vaccari, Monica, Raju, Jayadev, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Salem, Hosni K., Memeo, Lorenzo, Forte, Stefano, Singh, Neetu, Hamid, Roslida A., Ryan, Elizabeth P., Brown, Dustin G., Wise, John P., Sr., Wise, Sandra S., and Yasaei, Hemad
Abstract:: Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically,...
Resource Type:: Article
Full Text:: chemicals, senescence and immortality Disruptive chemicals, senescence and immortality Carnero, A

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

Creator:: Engström, Willhelm, Darbre, Philippa, Eriksson, Staffan, Gulliver, Linda, Hultman, Tove, Karamouzis, Michalis V., Klaunig, James E., Mehta, Rekha, Moorwood, Kim, Sanderson, Thomas, Sone, Hideko, Vadgama, Pankaj, Wagemaker, Gerard, Ward, Andrew, Singh, Neetu, Al-Mulla, Fahd, Al-Temaimi, Rabeah, Amedei, Amedeo, Colacci, Anna Maria, Vaccari, Monica, Mondello, Chiara, Scovassi, A. Ivana, Raju, Jayadev, Hamid, Roslida A., Memeo, Lorenzo, Forte, Stefano, Roy, Rabindra, Woodrick, Jordan, Salem, Hosni K., Ryan, Elizabeth, Brown, Dustin G., and Bisson, William H.
Abstract:: The aim of this work is to review current knowledge relating the established cancer hallmark, sustained cell proliferation to the existence of chemicals present as low dose mixtures in the environment. Normal cell proliferation is under tight control, i.e. cells respond to a signal to proliferate, and although most cells...
Resource Type:: Article

ScholarsArchive@OSU

BissonWilliamEnvironMoleToxAdaptationHumanArylSuppInfo.pdf

BissonWilliamEnvironMoleToxAdaptationHumanAryl.pdf

Chemical compounds from anthropogenic environment and immune evasion mechanisms: potential interactions

Adaptation of the human aryl hydrocarbon receptor to sense microbiota-derived indoles

Environmental immune disruptors, inflammation and cancer risk

Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?

Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis

Mechanisms of environmental chemicals that enable the cancer hallmark of evasion of growth suppression

Disruptive chemicals, senescence and immortality

The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling

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