Index Catalog // ScholarsArchive@OSU

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Resource Type:: Article

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Krausz, Kristopher W., Shi, Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Resource Type:: Article

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:: obesity-related metabolic dysfunction Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., & Gonzalez, F. J

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Li, Jing, Krausz, Kristopher W., Shik Jingmin, Brocker, Chad N., Desai, Dhimant, Amin, Shantu G., Bisson, William H., Liu, Yulan, Gavrilova, Oksana, Patterson, Andrew D., and Gonzalez, Frank J.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-b-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Bisson, William H., and et al.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...
Full Text:: obesity-related metabolic dysfunction Jiang, C., Xie, C., Lv, Y., Li, J., Krausz, K. W., Shi, J

Creator:: Jiang, Changtao, Xie, Cen, Lv, Ying, Bisson, William H., and et al.
Abstract:: The farnesoid X receptor (FXR) regulates bile acid, lipid and glucose metabolism. Here we show that treatment of mice with glycine-β-muricholic acid (Gly-MCA) inhibits FXR signalling exclusively in intestine, and improves metabolic parameters in mouse models of obesity. Gly-MCA is a selective high-affinity FXR inhibitor that can be administered orally...

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