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Creator:: Marley, Kevin, Bracha, Shay, and Seguin, Bernard
Abstract:: Background: Osteosarcoma (OS) is an aggressive and often fatal cancer that afflicts over 1000 humans and 10,000 dogs per year in the United States. Recent evidence suggests deregulation in the signaling triad, receptor activator of nuclear factor kappa B (RANK), its activating ligand (RANKL), and the RANKL inhibitor, osteoprotegerin (OPG)...
Resource Type:: Article
Full Text:: and RANKL Kevin Marley a,n, Shay Bracha a, Bernard Seguin b a Department of Clinical Sciences Oregon

Creator:: Marley, Kevin, Helfand, Stuart C., Simpson, Jennifer, Mata, John E., Tracewell, William G., Brownlee, Lisa, Bracha, Shay, and Séguin, Bernard
Abstract:: Background: Osteosarcoma in dogs and humans share many similarities and the dog has been described as an excellent model to study this disease. The median survival in dogs has not improved in the last 25 years. Taurolidine has been shown to be cytotoxic to canine and human osteosarcoma in vitro....
Resource Type:: Article
Full Text:: for dogs with osteosarcoma Marley et al. Journal of Experimental & Clinical Cancer Research 2013, 32

Creator:: Milovancev, Milan, Helfand, Stuart C., Marley, Kevin, Goodall, Cheri P., Löhr, Christiane V., and Bracha, Shay
Abstract:: Background: Canine oral fibrosarcoma (COF) is one of the most common oral tumors in dogs and carries a guarded prognosis due to a lack of effective systemic therapeutic options. Mastinib and imatinib are two commonly used tyrosine kinase inhibitors (TKIs) in veterinary oncology but their potential efficacy against COF is...
Resource Type:: Article
Full Text:: *, Stuart C. Helfand1, Kevin Marley1, Cheri P. Goodall1, Christiane V. Löhr2 and Shay Bracha1 Abstract

Creator:: Bracha, Shay, Viall, Austin, Goodall, Cheri, Stang, Bernadette, Ruaux, Craig, Seguin, Bernard, and Chappell, Patrick E.
Abstract:: BACKGROUND: The significance of the serotonergic system in bone physiology and, more specifically, the importance of the five hydroxytryptamine receptor 2A (5HTR2A) in normal osteoblast proliferation have been previously described; however the role of serotonin in osteosarcoma remains unclear. Particularly, the expression and function of 5HTR2A in canine osteosarcoma has...
Resource Type:: Article
Full Text:: , Dr. Kevin Marley, Dr. Vilma Yuzbasiyan-Gurkan and Jake Fischer for their help and support with this

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