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Filtering by: Creator Bradfute, Steven Date issued sim 2014-05-16

Induced IL-10 Splice Altering Approach to Antiviral Drug Discovery

Creator:

Panchal, Rekha G., Mourich, Dan V., Bradfute, Steven, Hauck, Laura L., Warfield, Kelly L., Iversen, Patrick L., and Bavari, Sina

Abstract:

Ebola virus causes an acute hemorrhagic fever lethal in primates and rodents. The contribution of host immune factors to pathogenesis has yet to be determined and may reveal efficacious targets for potential treatment. In this study, we show that the interleukin (IL)-10 signaling pathway modulates Ebola pathogenesis. IL-10 [superscript -...

Resource Type:

Article