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Filtering by: Committee Member Mcphail, Kerry Remove constraint Committee Member: Mcphail, Kerry Creator Brumsted, Corey J. Remove constraint Creator: Brumsted, Corey J.

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  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation