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Functional Analysis of Three Arabidopsis ARGONAUTES Using Slicer-Defective Mutants

Creator:

Carbonell, Alberto, Fahlgren, Noah, Garcia-Ruiz, Hernan, Gilbert, Kerrigan B., Montgomery, Taiowa A., Nguyen, Tammy, Cuperus, Josh T., and Carrington, James C.

Abstract:

In RNA-directed silencing pathways, ternary complexes result from small RNA-guided ARGONAUTE (AGO) associating with target transcripts. Target transcripts are often silenced through direct cleavage (slicing), destabilization through slicer-independent turnover mechanisms, and translational repression. Here, wild-type and active-site defective forms of several Arabidopsis thaliana AGO proteins involved in posttranscriptional silencing were...

Resource Type:

Article

Full Text:

Kerrigan B. Gilbert,a Taiowa A. Montgomery,b,1 Tammy Nguyen,b Josh T. Cuperus,b,2 and James C. Carringtona