Index Catalog // ScholarsArchive@OSU

Mediating role of arsenic in the relationship between diet and pregnancy outcomes: prospective birth cohort in Bangladesh

Creator:: Lin, Pi-I D., Bromage, Sabri, Mostofa, Md. Golam, Rahman, Mohammad, Allen, Joseph, Oken, Emily, Kile, Molly L., and Christiani, David C.
Abstract:: BackgroundEpidemiological evidence suggests that arsenic (As) exposure during pregnancy may reduce infant birth weight. One significant source of As exposure is diet; thus, As may indirectly affect infant growth by mediating the effect of maternal diet on birth weight (BW). This study evaluated the potential mediating effect of As in...
Resource Type:: Article

Reference-free deconvolution of DNA methylation data and mediation by cell composition effects

Creator:: Houseman, E. Andres, Kile, Molly L., Christiani, David C., Ince, Tan A., Kelsey, Karl T., and Marsit, Carmen J.
Abstract:: Background: Recent interest in reference-free deconvolution of DNA methylation data has led to several supervised methods, but these methods do not easily permit the interpretation of underlying cell types. Results: We propose a simple method for reference-free deconvolution that provides both proportions of putative cell types defined by their underlying...
Resource Type:: Article

In Utero Arsenic Exposure and Epigenome-Wide Associations in Placenta, Umbilical Artery and Human Umbilical Vein Endothelial Cells

Creator:: Cardenas, Andres, Houseman, E. Andres, Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mostofa, Golam, Wright, Robert O., Christiani, David C., and Kile, Molly L.
Abstract:: Exposure to arsenic early in life has been associated with increased risk of several chronic diseases and is believed to alter epigenetic programming in utero. In the present study, we evaluate the epigenome-wide association of arsenic exposure in utero and DNA methylation in placenta (n = 37), umbilical artery (n...
Resource Type:: Article

Neurodevelopmental outcomes among 2-to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water

Creator:: Rodrigues, Ema G., Bellinger, David C., Valeri, Linda, Hasan, Md Omar Sharif Ibne, Quamruzzaman, Quazi, Golam, Mostofa, Kile, Molly L., Christiani, David C., Wright, Robert O., and Mazumdar, Maitreyi
Abstract:: Background: The people of Bangladesh are currently exposed to high concentrations of arsenic and manganese in drinking water, as well as elevated lead in many regions. The objective of this study was to investigate associations between environmental exposure to these contaminants and neurodevelopmental outcomes among Bangladeshi children. Methods: We evaluated...
Resource Type:: Article

A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women

Creator:: Kile, Molly L., Faraj, Joycelyn M., Ronnenberg, Alayne G., Quamruzzaman, Quazi, Rahman, Mahmudar, Mostofa, Golam, Afroz, Sakila, and Christiani, David C.
Abstract:: Background: In the Ganges Delta, chronic arsenic poisoning is a health concern affecting millions of people who rely on groundwater as their potable water source. The prevalence of anemia is also high in this region, particularly among women. Moreover, arsenic is known to affect heme synthesis and erythrocytes and the...
Resource Type:: Article

Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort

Creator:: Kile, Molly L., Cardenas, Andres, Rodrigues, Ema, Mazumdar, Maitreyi, Dobson, Christine, Golam, Mostofa, Quamruzzaman, Quazi, Rahman, Mahmudar, and Christiani, David C.
Abstract:: BACKGROUND: The relationship between arsenic and birth weight is not well understood. OBJECTIVE: To evaluate the causal relationship between prenatal arsenic exposure and birth weight considering the potential mediation effects of gestational age (GA) and maternal weight gain (MWG) during pregnancy using structural equation models (SEMs). METHODS: A prospectively enrolled...
Resource Type:: Article

A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh

Creator:: Kile, Molly L., Rodrigues, Ema G., Mazumdar, Maitreyi, Dobson, Christine B., Diao, Nancy, Golam, Mostofa, Quamruzzaman, Quazi, Rahman, Mahmudar, and Christiani, David C.
Abstract:: BACKGROUND: Arsenic, a common groundwater pollutant, is associated with adverse reproductive health but few studies have examined its effect on maternal health. METHODS: A prospective cohort was recruited in Bangladesh from 2008–2011 (N = 1,458). At enrollment (<16 weeks gestational age [WGA]), arsenic was measured in personal drinking water using...
Resource Type:: Article

Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes

Creator:: Pan, Wen-Chi, Kile, Molly L., Seow, Wei Jie, Lin, Xihong, Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Lu, Quan, and Christiani, David C.
Abstract:: Abstract: Background: Chronic exposure to arsenic in drinking water is associated with increased risk of type 2 diabetes mellitus (T2DM) but the underlying molecular mechanism remains unclear. Objectives: This study evaluated the interaction between single nucleotide polymorphisms (SNPs) in genes associated with diabetes and arsenic exposure in drinking water on...
Resource Type:: Article

A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders

Creator:: Kile, Molly L., Fang, Shona, Baccarelli, Andrea A., Tarantini, Letizia, Cavallari, Jennifer, and Christiani, David C.
Abstract:: Abstract: Background: Exposure to pollutants including metals and particulate air pollution can alter DNA methylation. Yet little is known about intra-individual changes in DNA methylation over time in relationship to environmental exposures. Therefore, we evaluated the effects of acute-and chronic metal-rich PM[subscript 2.5] exposures on DNA methylation. Methods: Thirty-eight male...
Resource Type:: Article

Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh

Creator:: Seow, Wei Jie, Pan, Wen-Chi, Kile, Molly L., Baccarelli, Andrea A., Quamruzzaman, Quazi, Rahman, Mahmuder, Mahiuddin, Golam, Mostofa, Golam, Lin, Xihong, and Christiani, David C.
Abstract:: BACKGROUND: Chronic exposure to arsenic is associated with skin lesions. However, it is not known whether reducing arsenic exposure will improve skin lesions. OBJECTIVE: We evaluated the association between reduced arsenic exposures and skin lesion recovery over time. METHODS: A follow-up study of 550 individuals was conducted in 2009-2011 on...
Resource Type:: Article

ScholarsArchive@OSU

Mediating role of arsenic in the relationship between diet and pregnancy outcomes: prospective birth cohort in Bangladesh

Reference-free deconvolution of DNA methylation data and mediation by cell composition effects

In Utero Arsenic Exposure and Epigenome-Wide Associations in Placenta, Umbilical Artery and Human Umbilical Vein Endothelial Cells

Neurodevelopmental outcomes among 2-to 3-year-old children in Bangladesh with elevated blood lead and exposure to arsenic and manganese in drinking water

A cross sectional study of anemia and iron deficiency as risk factors for arsenic-induced skin lesions in Bangladeshi women

Estimating effects of arsenic exposure during pregnancy on perinatal outcomes in a Bangladeshi cohort

A prospective cohort study of the association between drinking water arsenic exposure and self-reported maternal health symptoms during pregnancy in Bangladesh

Genetic Susceptible Locus in NOTCH2 Interacts with Arsenic in Drinking Water on Risk of Type 2 Diabetes

A panel study of occupational exposure to fine particulate matter and changes in DNA methylation over a single workday and years worked in boilermaker welders

Arsenic Reduction in Drinking Water and Improvement in Skin Lesions: A Follow-Up Study in Bangladesh

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