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Filtering by: Creator Krausz, Aimee Creator Da Costa Neto, Alexandre Batista

S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology

Creator:

Mordorski, Breanne, Pelgrift, Robert, Adler, Brandon, Krausz, Aimee, da Costa Neto, Alexandre Batista, Liang, Hongying, Gunther, Leslie, Clendaniel, Alicea, Harper, Stacey, Friedman, Joel M., Nosanchuk, Joshua D., Nacharaju, Parimala, and Friedman, Adam J.

Abstract:

Nitric oxide (NO) is an essential agent of the innate immune system which exhibits multi-mechanistic antimicrobial activity. Previously, increased antimicrobial activity against E. coli with nitric oxide releasing nanoparticles (NO-np) was demonstrated when combined with glutathione, versus NO-np alone, due to formation of S-nitrosoglutathione (GSNO), a potent transnitrosylating agent. To...

Resource Type:

Article

Full Text:

Pelgrift, BA2 Aimee Krausz, BA1 Brandon Adler, BA1 Alexandre Batista da Costa Neto 2 Hongying Liang3