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Filtering by: Creator Eisfeld, Amie J. Creator Selinger, Christian

Integrated Omics Analysis of Pathogenic Host Responses during Pandemic H1N1 Influenza Virus Infection: The Crucial Role of Lipid Metabolism

Creator:

Tisoncik-Go, Jennifer, Gasper, David J., Kyle, Jennifer E., Eisfeld, Amie J., Selinger, Christian, Hatta, Masato, Morrison, Juliet, Korth, Marcus J., Zink, Erika M., Kim, Young-Mo, Schepmoes, Athena A., Nicora, Carrie D., Purvine, Samuel O., Weitz, Karl K., Peng, Xinxia, Green, Richard R., Tilton, Susan C., Webb-Robertson, Bobbie-Jo, Waters, Katrina M., Metz, Thomas O., Smith, Richard D., Kawaoka, Yoshihiro, Suresh, M., Josset, Laurence, and Katze, Michael G.

Abstract:

Pandemic influenza viruses modulate proinflammatory responses that can lead to immunopathogenesis. We present an extensive and systematic profiling of lipids, metabolites, and proteins in respiratory compartments of ferrets infected with either 1918 or 2009 human pandemic H1N1 influenza viruses. Integrative analysis of high-throughput omics data with virologic and histopathologic data...

Resource Type:

Article